Details information on Satellite virus

Satellites are sub-viral agents, composed of nucleic acid molecules that depend for their productive multiplication on co-infection of a host cell with a helper virus. Satellite nucleic acids have subsequently distinct nucleotide sequences from those of the genomes of either their helper virus or host. When a satellite encodes the coat protein in which protein its nucleic acid is encapsidated, it is referred to as a satellite virus.

In brief, it can be said that when a virus is depended on another virus for its proper replication in a host cell, it is called satellite virus and such a situation is called satellism. Thje virus which helps the satellite virus to successfully infect and replicate in host cell is called activator.

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Interleukin 27 balances the immune response to influenza and reduces lung damage

The recent identification of Interleukin-27 (IL-27p28/EBV-induced gene 3) and IL-27R(WSX-1/gp130) has provided new insights for the biology of IL-6/IL-12 family cytokines.Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits; Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-30). IL-27 is produced by antigen-presenting cells. Initial studies indicated that IL-27 can directly regulate T and B-lymphocytes functions and suggested an important role for it in promoting Th1 type responses. The effects of IL-27 are eliciting by its interaction with a specific cell-surface receptor complex composed of two proteins known as IL27R and gp130.

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